This is a very rare condition where small tumors known as Gastrinoma developed in the digestive tract. Specially on the Stomach but in the other part also like small intestine, Pancreas etc.
This tumors secrete Gastrin which is a hormone, in large amount. Gastrin stimulates gastric acid secretion a great deal. The excessive secretion of gastric acid try to neutralize the mucous membrane on the inner part of the stomach and therefore causes inflammation here and there which ultimately turn into ulcer. In common tounge we called it gastric ulcer.
Once a people got effected with this syndrome are often hard to cure.
This syndrome can appear at any age but the people in between 30 - 60 age group are more vulnerable to this.
Once developed the tumours can spread upto liver and lymph nodes and turn to cancer.
We all know our cell membrane possesses different types of protein some of them are peripheral and others are integral. Aquaporin are integral proteins found in the cells which help to transport water from one cell to another. According to their function they are named as water channel . Just take a look at their name Aquaporin , here Aqua means water and porin means pore or channel. So it is clear from there name, that they form pores on the surface of biological membranes, and mainly water transports through it. This channels are composed mainly of six transmembrane Alpha helices. As they are integral proteins so they embedded in the cell membrane, the amino and carboxyl ends face the inside half of the cell. Aquaporin creats four part clusters in the cell membrane, they are the monomers and all of them serves as water channel. In mammals there are 13 known types are present ,it is astonishing that among them 6 are present in kidney ...
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