We all know our cell membrane possesses different types of protein some of them are peripheral and others are integral.
Aquaporin are integral proteins found in the cells which help to transport water from one cell to another. According to their function they are named as water channel.
Just take a look at their name Aquaporin , here Aqua means water and porin means pore or channel. So it is clear from there name, that they form pores on the surface of biological membranes, and mainly water transports through it.
This channels are composed mainly of six transmembrane Alpha helices. As they are integral proteins so they embedded in the cell membrane, the amino and carboxyl ends face the inside half of the cell.
Aquaporin creats four part clusters in the cell membrane, they are the monomers and all of them serves as water channel.
In mammals there are 13 known types are present ,it is astonishing that among them 6 are present in kidney and others are present in brain, G I tract and other cells.
If mutation occurs in the gene which is responsible for the synthesis of aquaporin that causes Diabetes Insipidus. Humans hereditary nephrogenic Diabetes Insipidus is a classic example of that (causes due to mutation of the Aquaporin 2 gene).
These are one one kind of phosphorus containing organic chemicals (known as organophosphate ) which distrupt the total procedure of neuro muscular transmission by inhibiting the enzyme Acetyl choline estarase at the synaptic cleft. Nerve gases divide into two subclasses 1. G series : Tabun, Satin, Soman are common among them. 2. V series : VE, VG, VM, VR. Some insecticides such as Dichlorvos , Parathion , Malathion fall in this genre.
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